Ana Aguiar-Ricardo - Synopsis

This lecture will address specific challenges on the bottom-up assembling of complex composite formulations.

Special attention will be given to the integration of supercritical fluid assisted spray drying with other technologies for the generation of precision formulations, for the delivery of small molecule therapeutics to biologic drugs and nucleic acids, namely: i) Nano-in-microparticles solid dosage forms for pulmonary delivery; ii) Micronized layer-by-layer siRNA powders; iii) Nano-in-micro POxylated polyurea dendrimer solid dosage forms; iv) Liposomal dry powder formulations with hydrophobic and hydrophilic compounds.

Our results demonstrate the potential of scCO2-assisted technologies for particle engineering of pharmaceutical materials, especially in the manufacture of pulmonary drug delivery systems, considering the tight requirements necessary for the final aerosol properties.